Twinscan

A prediction program by Ian Korf, Paul Flicek, and Michael Brent which builds on Genscan and incorporates sequence homology into the gene predictions.

References

1. Korf I, Flicek P, Duan D, and Brent MR. Integrating genomic homology into gene structure prediction. Bioinformatics. 2001;17 Suppl 1:S140-8.
2. Flicek P, Keibler E, Hu P, Korf I, and Brent MR. Leveraging the mouse genome for gene prediction in human: from whole-genome shotgun reads to a global synteny map. Genome Res. 2003 Jan;13(1):46-54. DOI:10.1101/gr.830003 |
3. Wang M, Buhler J, and Brent MR. The effects of evolutionary distance on TWINSCAN, an algorithm for pair-wise comparative gene prediction. Cold Spring Harb Symp Quant Biol. 2003;68:125-30.
4. Tenney AE, Brown RH, Vaske C, Lodge JK, Doering TL, and Brent MR. Gene prediction and verification in a compact genome with numerous small introns. Genome Res. 2004 Nov;14(11):2330-5. DOI:10.1101/gr.2816704 |