Seg

A program for filtering low complexity regions in amino acid sequences seg,seg2. Residues that have been masked are represented as "X" in an alignment, but it can also be run as a standalone program as well. The module Bio::Tools::Run::Seg can assist.

It is useful to run seg on sequences before running FASTA so that the -S option can be used to mask sequence portions in the search phase but allow them to participate in the final alignment. An example of seg running on a FASTA sequence format]] sequence database is shown here

$ seg database -q -z 1 > database.seg

It can be found here

References

<biblio>

1. seg pmid=8743706
2. seg2 Wootton JC and Federhen S. Statistics of local complexity in amino acid sequences and sequence databases. Computers in Chemistry 1996; 17:149-163.

</biblio>