From BioPerl
<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE HPRDr2 SYSTEM "hprdr2.dtd">
<HPRDr2 xmlns="org:hprd:dtd:hprdr2">
<protein isoform="1" version="1" id="HPRD_05510">
<title>Endothelial differentiation gene 8</title>
<alt_title>Sphingosine 1 phosphate receptor EDG8</alt_title>
<alt_title>S1P Receptor EDG8</alt_title>
<alt_title>Sphingosine 1 phosphate receptor Edg8</alt_title>
<alt_title>SPPR</alt_title>
<alt_title>Putative G protein coupled receptor</alt_title>
<alt_title>Endothelial differentiation, sphingolipid G protein coupled receptor, 8</alt_title>
<alt_title>Hypothetical protein FLJ90180</alt_title>
<alt_title>GPCR</alt_title>
<omim>605146</omim>
<gene_symbol>EDG8 </gene_symbol>
<gene_map_locus>
<title>19p13.2</title>
</gene_map_locus>
<seq_entry source="Ref-Seq">
<entry_cdna>NM_030760.2</entry_cdna>
<entry_protein>NP_110387.1</entry_protein>
</seq_entry>
<molecular_weight>41778</molecular_weight>
<entry_sequence>
<cdna length="2306">gcgcggccca tggagtcggg gctgctgcgg
ccggcgccgg tgagcgaggt catcgtcctg
cattacaact acaccggcaa gctccgcggt
gcgcgctacc agccgggtgc cggcctgcgc
gccgacgccg tggtgtgcct ggcggtgtgc
gccttcatcg tgctagagaa tctagccgtg
ttgttggtgc tcggacgcca cccgcgcttc
cacgctccca tgttcctgct cctgggcagc
ctcacgttgt cggatctgct ggcaggcgcc
gcctacgccg ccaacatcct actgtcgggg
ccgctcacgc tgaaactgtc ccccgcgctc
tggttcgcac gggagggagg cgtcttcgtg
gcactcactg cgtccgtgct gagcctcctg
gccatcgcgc tggagcgcag cctcaccatg
gcgcgcaggg ggcccgcgcc cgtctccagt
cgggggcgca cgctggcgat ggcagccgcg
gcctggggcg tgtcgctgct cctcgggctc
ctgccagcgc tgggctggaa ttgcctgggt
cgcctggacg cttgctccac tgtcttgccg
ctctacgcca aggcctacgt gctcttctgc
gtgctcgcct tcgtgggcat cctggccgcg
atctgtgcac tctacgcgcg catctactgc
caggtacgcg ccaacgcgcg gcgcctgccg
gcacggcccg ggactgcggg gaccacctcg
acccgggcgc gtcgcaagcc gcgctcgctg
gccttgctgc gcacgctcag cgtggtgctc
ctggcctttg tggcatgttg gggccccctc
ttcctgctgc tgttgctcga cgtggcgtgc
ccggcgcgca cctgtcctgt actcctgcag
gccgatccct tcctgggact ggccatggcc
aactcacttc tgaaccccat catctacacg
ctcaccaacc gcgacctgcg ccacgcgctc
ctgcgcctgg tctgctgcgg acgccactcc
tgcggcagag acccgagtgg ctcccagcag
tcggcgagcg cggctgaggc ttccgggggc
ctgcgccgct gcctgccccc gggccttgat
gggagcttca gcggctcgga gcgctcatcg
ccccagcgcg acgggctgga caccagcggc
tccacaggca gccccggtgc acccacagcc
gcccggactc tggtatcaga accggctgca
gactgacacc ctcggcccac gactgtcttc
ccaagtttta cagacttgtt ctttttacat
aaaggaattt gtaggaaatg cagccaaagg
tgcagtcgga aaagatgcag gggaaatgta
tttatgcagc gacaccccac aatgtgaaca
aacagacaaa aaatctgtgc cctcgtggaa
ttgacgttct gcttgggaac acagaaaaga
actcggtgat gaaataatgg agatgattcc
agtgacaaac gacagagatg gtgatggtgg
tcagggaaga cctctctgca gaggtagtga
cttgtgatgt gagctgagac ctctgtcctg
ggaagaccaa aagaaaagca tttcaggatg
agggaatggc atgcgcaaag gccctgaggc
tgaaatgtgc ccatgtgttc taagaaatgc
agcgatgctg gtgtgcctgg agcagggacg
gagggggaga atgggaggag acaaggagct
gaaggagtag ttcccgaagg accttgtggg
tgatatagag gacttcgctt ttgctctgag
tgaggtggga gccatagaag cttctaagca
gaagagggac ttgccctaat tcaggtgatc
acaggtgtct tgtggcctcc atgggaggtt
gaaaaccaca gaaggtgaag gggggctgca
ctgagccaca ggaacaatga tggagattcc
agctaagccc agaccccgtg gattctagat
agattttaga ggcagcagac agaattactg
aggaattgag tgtaagagtg gaataaagtt
atcaaggaca atgccaaggg tggggcaccc
ccaaatttga ctttgggaga ctcagccaaa
tcctatctgg taataaaatt tcttttttat
ttttcttttc tttctttctt tctttctttc
tttttttttt tttgagttgg gatcttgtgc
tctgtcaccc aggctggagt gcaatgggca
caattatagc tcactgcagc ctggaactcc
tgggatcaag cctggagttc ctgcttcagc
ctccctagta gctgggacta caggcatgca
ccaccatgcc cagttaataa aatttcttca
aatgcaaaaa aaaaaaaaaa aaaaaa
</cdna>
<cdna_utr5 start="1" end="9"/>
<cdna_coding start="10" end="1206"/>
<cdna_utr3 start="1207" end="2306"/>
<protein_sequence length="398">mesgllrpap vsevivlhyn ytgklrgary
qpgaglrada vvclavcafi vlenlavllv
lgrhprfhap mflllgsltl sdllagaaya
anillsgplt lklspalwfa reggvfvalt
asvlsllaia lersltmarr gpapvssrgr
tlamaaaawg vslllgllpa lgwnclgrld
acstvlplya kayvlfcvla fvgilaaica
lyariycqvr anarrlparp gtagttstra
rrkprslall rtlsvvllaf vacwgplfll
llldvacpar tcpvllqadp flglamansl
lnpiiytltn rdlrhallrl vccgrhscgr
dpsgsqqsas aaeasgglrr clppgldgsf
sgsersspqr dgldtsgstg spgaptaart
lvsepaad
</protein_sequence>
</entry_sequence>
<protein_domain_architecture>
<domain domain_source="smart" end="62" type="domain"
start="40">
<title>TM</title>
</domain>
<domain domain_source="smart" end="93" type="domain"
start="71">
<title>TM</title>
</domain>
<domain domain_source="smart" end="130" type="domain"
start="108">
<title>TM</title>
</domain>
<domain domain_source="smart" end="173" type="domain"
start="151">
<title>TM</title>
</domain>
<domain domain_source="smart" end="215" type="domain"
start="193">
<title>TM</title>
</domain>
<domain domain_source="smart" end="269" type="domain"
start="247">
<title>TM</title>
</domain>
<domain domain_source="smart" end="306" type="domain"
start="284">
<title>TM</title>
</domain>
</protein_domain_architecture>
<expressions>
<expression>
<title>Keratinocyte</title>
<pubmed>12648236</pubmed>
</expression>
<expression>
<title>Cerebral cortex</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Frontal lobe</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Parietal lobe</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Occipital lobe</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Temporal lobe</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Pons</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Amygdaloid nucleus</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Cerebellum</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Caudate nucleus</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Hippocampus</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Medulla oblongata</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Putamen</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Leukocyte</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Lymph node</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Bone marrow</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Trachea</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Thalamus</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Aorta</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Atrium</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Ventricle</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Oesophagus</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Stomach</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Duodenum</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Jejunum</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Ileum</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Caecum</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Vermiform appendix</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Colon</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Rectum</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Kidney</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Skeletal muscle</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Spleen</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Thymus</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Lung</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Placenta</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Uterus</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Prostate</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Testis</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Ovary</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Liver</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Adrenal gland</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Thyroid gland </title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Salivary gland</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Fetus</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Urinary bladder</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Corpus callosum</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Nucleus accumbens</title>
<pubmed>11705398</pubmed>
</expression>
<expression>
<title>Pancreas</title>
<pubmed>11705398</pubmed>
</expression>
</expressions>
<functions>
<molecular_class>G protein coupled receptor</molecular_class>
<molecular_function>
<title>G-protein coupled receptor activity</title>
<goid>0004930</goid>
</molecular_function>
<biological_processes>
<biological_process>
<title>Signal transduction</title>
<goid>0007165</goid>
</biological_process>
<biological_process>
<title>Cell communication </title>
<goid>0007154</goid>
</biological_process>
</biological_processes>
</functions>
<cellular_component>
<primary>
<title>plasma membrane</title>
<go_id>GO:0005886</go_id>
<go_abbreviation>TAS</go_abbreviation>
<pubmed>11331101</pubmed>
</primary>
</cellular_component>
<interactions>
<entrySet xmlns="net:sf:psidev:mi"
xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
xsi:schemaLocation="net:sf:psidev:mi http://psidev.sourceforge.net/mi/xml/src/MIF.xsd"
level="1" version="1">
<entry>
<source>
<names>
<shortLabel>HPRD</shortLabel>
<fullName>Human Protein Reference Database</fullName>
</names>
<bibref>
<xref>
<primaryRef db="PubMed" id="14525934"/>
<secondaryRef db="PubMed" id="14681466"/>
</xref>
</bibref>
</source>
<availabilityList>
<availability id="copyright">
This data is copyrighted by Johns Hopkins University.
Commercial entities may not use this without prior licensing
authorization. Other databases must agree to enforce the same
licensing guidelines before making this data public on their website.
</availability>
</availabilityList>
<interactorList>
<proteinInteractor id="ID_HPRD_05510">
<names>
<shortLabel>Endothelial differentiation gene 8</shortLabel>
</names>
<xref>
<primaryRef db="HPRD" id="HPRD_05510"/>
<secondaryRef version="1" db="Ref-Seq"
id="NP_110387"/>
<secondaryRef db="Swiss-Prot"
id="Q9H228"/>
<secondaryRef db="Locus-Link" id="53637"/>
<secondaryRef db="Unigene"
id="501561"/>
</xref>
<organism ncbiTaxId="9606">
<names>
<shortLabel>Human</shortLabel>
<fullName>Homo sapiens</fullName>
</names>
</organism>
<sequence>mesgllrpap vsevivlhyn ytgklrgary
qpgaglrada vvclavcafi vlenlavllv
lgrhprfhap mflllgsltl sdllagaaya
anillsgplt lklspalwfa reggvfvalt
asvlsllaia lersltmarr gpapvssrgr
tlamaaaawg vslllgllpa lgwnclgrld
acstvlplya kayvlfcvla fvgilaaica
lyariycqvr anarrlparp gtagttstra
rrkprslall rtlsvvllaf vacwgplfll
llldvacpar tcpvllqadp flglamansl
lnpiiytltn rdlrhallrl vccgrhscgr
dpsgsqqsas aaeasgglrr clppgldgsf
sgsersspqr dgldtsgstg spgaptaart
lvsepaad
</sequence>
</proteinInteractor>
<proteinInteractor id="ID_HPRD_05093">
<names>
<shortLabel>Guanine nucleotide binding protein, alpha 12</shortLabel>
</names>
<organism ncbiTaxId="40674">
<names>
<shortLabel>Mammals</shortLabel>
<fullName>Mammalia</fullName>
</names>
</organism>
</proteinInteractor>
<proteinInteractor id="ID_HPRD_00756">
<names>
<shortLabel>G protein, alpha inhibiting 1</shortLabel>
</names>
<organism ncbiTaxId="40674">
<names>
<shortLabel>Mammals</shortLabel>
<fullName>Mammalia</fullName>
</names>
</organism>
</proteinInteractor>
<proteinInteractor id="ID_HPRD_00757">
<names>
<shortLabel>Guanine nucleotide binding protein, alpha 'other'</shortLabel>
</names>
<organism ncbiTaxId="40674">
<names>
<shortLabel>Mammals</shortLabel>
<fullName>Mammalia</fullName>
</names>
</organism>
</proteinInteractor>
</interactorList>
<interactionList>
<interaction>
<availabilityRef ref="copyright"/>
<experimentList>
<experimentDescription
id="I10656758048004_vt">
<bibref>
<xref>
<primaryRef
db="PubMed" id="11069896"/>
</xref>
</bibref>
<interactionDetection>
<names>
<shortLabel>vt</shortLabel>
<fullName>in vitro</fullName>
</names>
<xref>
<primaryRef db="IOB"
id="IOB:0002"/>
</xref>
</interactionDetection>
</experimentDescription>
</experimentList>
<participantList>
<proteinParticipant>
<proteinInteractorRef
ref="ID_HPRD_05093"/>
</proteinParticipant>
<proteinParticipant>
<proteinInteractorRef
ref="ID_HPRD_05510"/>
</proteinParticipant>
</participantList>
<xref>
<primaryRef db="HPRD" id="HPRD_05510"/>
</xref>
<attributeList>
<attribute name="HPRD Author">sandeep</attribute>
<attribute name="last_updated">2_20_2005</attribute>
</attributeList>
</interaction>
<interaction>
<availabilityRef ref="copyright"/>
<experimentList>
<experimentDescription
id="I10993217343120_vv">
<bibref>
<xref>
<primaryRef
db="PubMed" id="11069896"/>
</xref>
</bibref>
<interactionDetection>
<names>
<shortLabel>vv</shortLabel>
<fullName>in vivo</fullName>
</names>
<xref>
<primaryRef db="IOB"
id="IOB:0001"/>
</xref>
</interactionDetection>
</experimentDescription>
</experimentList>
<participantList>
<proteinParticipant>
<proteinInteractorRef
ref="ID_HPRD_00756"/>
</proteinParticipant>
<proteinParticipant>
<proteinInteractorRef
ref="ID_HPRD_05510"/>
</proteinParticipant>
</participantList>
<xref>
<primaryRef db="HPRD" id="HPRD_05510"/>
</xref>
<attributeList>
<attribute name="HPRD Author">sandeep</attribute>
<attribute name="last_updated">2_20_2005</attribute>
</attributeList>
</interaction>
<interaction>
<availabilityRef ref="copyright"/>
<experimentList>
<experimentDescription
id="I10656757483361_vt">
<bibref>
<xref>
<primaryRef
db="PubMed" id="11069896"/>
</xref>
</bibref>
<interactionDetection>
<names>
<shortLabel>vt</shortLabel>
<fullName>in vitro</fullName>
</names>
<xref>
<primaryRef db="IOB"
id="IOB:0002"/>
</xref>
</interactionDetection>
</experimentDescription>
</experimentList>
<participantList>
<proteinParticipant>
<proteinInteractorRef
ref="ID_HPRD_00757"/>
</proteinParticipant>
<proteinParticipant>
<proteinInteractorRef
ref="ID_HPRD_05510"/>
</proteinParticipant>
</participantList>
<xref>
<primaryRef db="HPRD" id="HPRD_05510"/>
</xref>
<attributeList>
<attribute name="HPRD Author">sandeep</attribute>
<attribute name="last_updated">2_20_2005</attribute>
</attributeList>
</interaction>
</interactionList>
</entry>
</entrySet>
</interactions>
<non_protein_interactions>
<non_protein_interaction complex="no">
<n_interactor db="HPRD">05510</n_interactor>
<n_interactor db="none_specified">Sphingosine 1 phosphate </n_interactor>
<exp_type>in vitro</exp_type>
<pubmed>11069896</pubmed>
</non_protein_interaction>
</non_protein_interactions>
<EXTERNAL_LINKS>
<SwissProt>Q9H228</SwissProt>
<locusLink>53637</locusLink>
<unigene>501561</unigene>
<otherResources>None</otherResources>
<PDB></PDB>
</EXTERNAL_LINKS>
<author>
<annotator>sandeep</annotator>
</author>
<last_updated>2_20_2005</last_updated>
</protein>
</HPRDr2>
